RAD-150 — Safety, Research, Risks & Legal Status

Not medical advice. RAD-150 is discussed here for informational and harm-reduction purposes only. We do not endorse use, and any dosing context is informational, not a protocol.

Also known as	RAD150, RAD-140 ester, TLB-150
Category	SARM
parent_compound	RAD-140 (Testolone); more preclinical data exists
half_life_intent	Esterification designed to extend duration vs RAD-140
US legal status	Not FDA-approved for human use. Sold as a research chemical only. WADA-banned. No approved pharmaceutical product.

What is RAD-150?

Modified version of RAD-140 (esterified prodrug form). Selective androgen receptor modulator designed to improve pharmacokinetics over RAD-140. Synthetic nonsteroidal compound targeting androgen receptors.

How it works

Esterification of RAD-140 creates prodrug that extends duration via delayed ester hydrolysis in vivo. Once activated, binds androgen receptor with similar selectivity as parent compound.

Background & history

RAD-140 developed by Radius Health; shown anabolic efficacy in preclinical models. RAD-150 (TLB-150) is analog modification designed to prolong half-life. Neither advanced to human clinical trials.

What the research says

Very limited human evidence; primarily animal studies. RAD-140 (parent) has more preclinical data showing anabolic effects. RAD-150 modification intended to extend half-life, but human data is essentially absent. Testosterone suppression expected.

Reported effects

Reported anabolic muscle effects in preclinical models
Studied for bone density potential (parent compound data)
Expected strong androgen receptor activity
Designed for extended half-life vs RAD-140
Suppression of endogenous testosterone likely

Dosing & administration (informational)

Preclinical studies on RAD-140 established dose-response relationships for muscle and bone endpoints. RAD-150 pharmacokinetics not characterized in any published human work.

This is general research/context information, not medical advice or a recommended protocol.

Safety & side effects

No human safety data for RAD-150 specifically
Testosterone suppression and testicular atrophy expected
Liver function impact in humans unknown
Long-acting ester profile means prolonged suppression
WADA-banned; sport-prohibited
Unverified sourcing and purity risk extremely high

Drug & supplement interactions

Additive testosterone suppression with other androgens or SARMs
Prolonged ester hydrolysis may delay peak effects and duration
Unknown interaction with hepatic esterase systems
May alter sex hormone-binding globulin dynamics over extended period

Who should avoid it

Concurrent use with anabolic steroids or other SARMs
In individuals with hepatic dysfunction or ester-metabolism disorders
In those with existing hypogonadism or sexual dysfunction
During sport competition (WADA-banned) or professional athletics

How it is commonly combined

No human evidence supports multi-compound use; long-acting ester form compounds toxicological uncertainty and delayed recovery.

Legal & regulatory. Not FDA-approved for human use. Sold as a research chemical only. WADA-banned. No approved pharmaceutical product.

Quality & harm reduction

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Lab testing & harm-reduction tools

If you are going to research a compound, verifying identity and purity is the single most protective step. Independent analytical testing and sterile-handling supplies reduce risk.

Compare testing options

Frequently asked questions

How is RAD-150 different from RAD-140?

Esterified modification to extend half-life and duration. Both are research chemicals with no human trials.

Is the longer half-life safer?

No. It means prolonged testosterone suppression and extended exposure to unknown effects.

Any human data?

No published trials for RAD-150. RAD-140 has slightly more preclinical research, but human evidence is absent.

What are the main risks?

Testosterone suppression, unknown organ effects, WADA-banned status, unverified product purity, and experimental in humans.

How long does suppression last?

Unknown; extended ester hydrolysis may delay recovery compared to RAD-140, but no human data exists.

References & further reading

WADA Prohibited List (SARMs and androgen receptor agonists)
FDA regulatory guidance on prodrug formulation and SARM development
PubMed RAD-140 preclinical anabolic pharmacology and selectivity data